At Z7 Biotech we specialise in cold-start discovery and bespoke assay development, supporting challenging targets. We partner with your project teams to confirm compound target engagement and accelerate your hit-to-lead strategy.
Our integrated platform combines advanced technologies with deep pharmacological expertise to define mechanism of action from early discovery through development. Below is an overview of our services and specialist target capabilities.
TARGETS
G-Protein Coupled Receptors
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GPCRs (Class A, B, and C) - Small molecule, peptide, lipid, and proton-sensing receptors
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Orphan GPCRs - Cardiovascular, oncology, immunology, and neuroscience targets
Other Membrane Protein Targets
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Ion channels
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Transporters
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Receptor tyrosine kinases (RTKs)
Soluble Targets
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DNA exonucleases Kinases, phosphatases, and epigenetic regulators
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Proteases and protein-protein interactions
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Transcription factors and signalling mediators
SERVICES OFFERED
Tracerless thermal shift-based assays
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ThermoBRET - Membrane protein target engagement
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IsoThermoBRET - Ligand affinity quantification
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ModuMelt - Detection of allosteric ligands
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SolThermoBRET - Soluble protein target engagement in whole cell or lysate
HOW WE WORK
From initial consultation to final reporting, our work is guided by our core values of Excellence, Innovation, and Collaboration.
We design and develop assays tailored to your specific objectives, ensuring that experimental strategies align with your project goals. Drawing on extensive experience across academia and industry, we identify critical considerations early - helping to de-risk development and maximise data quality.
Beyond delivery, we interpret results within a broader scientific and technical context. Our deep understanding of the technologies we use allows us to translate data into actionable insights, supporting confident decision-making in complex biological systems.
Typical Project Workflow - Start to finish
